Trans-2-enoyl-CoA reductase (NADPH)

In enzymology, a trans-2-enoyl-CoA reductase (NADPH) (EC 1.3.1.38) is an enzyme that catalyzes the chemical reaction

trans-2,3-dehydroacyl-CoA + NADPH + H⁺ ${\displaystyle \rightleftharpoons }$ acyl-CoA + NADP⁺

trans-2-enoyl-CoA reductase (NADPH)
Identifiers
EC no.	1.3.1.38
CAS no.	77649-64-0
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Thus, the three substrates of this enzyme are trans-2,3-dehydroacyl-CoA, NADPH, and H⁺, whereas its two products are acyl-CoA and NADP⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is acyl-CoA:NADP+ trans-2-oxidoreductase. Other names in common use include NADPH-dependent trans-2-enoyl-CoA reductase, reductase, trans-enoyl coenzyme A, and trans-2-enoyl-CoA reductase (NADPH). This enzyme participates in fatty acid elongation in mitochondria and polyunsaturated fatty acid biosynthesis.