Trimethylamine-N-oxide reductase (cytochrome c)

In enzymology, a trimethylamine-N-oxide reductase (cytochrome c) (EC 1.7.2.3) is an enzyme that catalyzes the chemical reaction

trimethylamine + 2 (ferricytochrome c)-subunit + H₂O ${\displaystyle \rightleftharpoons }$ trimethylamine N-oxide + 2 (ferrocytochrome c)-subunit + 2 H⁺

trimethylamine-N-oxide reductase (cytochrome c)
Identifiers
EC no.	1.7.2.3
CAS no.	37256-34-1
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The 3 substrates of this enzyme are trimethylamine, (ferricytochrome c)-subunit, and H₂O, whereas its 3 products are trimethylamine N-oxide, (ferrocytochrome c)-subunit, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on other nitrogenous compounds as donors with a cytochrome as acceptor. The systematic name of this enzyme class is trimethylamine:cytochrome c oxidoreductase. Other names in common use include TMAO reductase, and TOR. This enzyme participates in two-component system - general.