Triphosphate—protein phosphotransferase

In enzymology, a triphosphate-protein phosphotransferase (EC 2.7.99.1) is an enzyme that catalyzes the chemical reaction

triphosphate + [microsomal-membrane protein] ${\displaystyle \rightleftharpoons }$ diphosphate + phospho-[microsomal-membrane protein]

diphosphate-protein phosphotransferase
Identifiers
EC no.	2.7.99.1
CAS no.	74092-32-3
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Thus, the two substrates of this enzyme are triphosphate and microsomal-membrane protein, whereas its two products are diphosphate and [[phospho-[microsomal-membrane protein]]].

Classification

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups that are not covered by other phosphotransferase families.

Nomenclature

The systematic name of this enzyme class is triphosphate:[microsomal-membrane-protein] phosphotransferase. Other names in common use include diphosphate:microsomal-membrane-protein O-phosphotransferase, (erroneous), DiPPT (erroneous), pyrophosphate:protein phosphotransferase (erroneous), diphosphate-protein phosphotransferase (erroneous), diphosphate:[microsomal-membrane-protein] O-phosphotransferase, and (erroneous).