Tryptophan 2'-dioxygenase

In enzymology, a tryptophan 2'-dioxygenase (EC 1.13.99.3) is an enzyme that catalyzes the chemical reaction

L-tryptophan + O
₂ + H⁺
${\displaystyle \rightleftharpoons }$ (indol-3-yl)glycolaldehyde + CO
₂ + NH⁺
₄

tryptophan 2'-dioxygenase
Identifiers
EC no.	1.13.99.3
CAS no.	64295-81-4
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Thus, the 3 substrates of this enzyme are L-tryptophan, O
₂ and H⁺
, whereas its 3 products are (indol-3-yl)glycolaldehyde, CO
₂, and NH⁺
₄.

Classification

This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O₂ as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O miscellaneous.

Nomenclature

The systematic name of this enzyme class is L-tryptophan:oxygen 2'-oxidoreductase (side-chain-cleaving). Other names in common use include indole-3-alkane alpha-hydroxylase, tryptophan side-chain alpha,beta-oxidase, tryptophan side chain oxidase II, tryptophan side-chain oxidase, TSO, indolyl-3-alkan alpha-hydroxylase, tryptophan side chain oxidase type I, TSO I, TSO II, and tryptophan side chain oxidase.

Biological role

This enzyme participates in tryptophan metabolism. It employs one cofactor, heme.