UBR2

E3 ubiquitin-protein ligase UBR2 is an enzyme that in humans is encoded by the UBR2 gene.^[5]

UBR2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3NY2, 3NY3
Identifiers
Aliases	UBR2, C6orf133, bA49A4.1, dJ242G1.1, dJ392M17.3, ubiquitin protein ligase E3 component n-recognin 2
External IDs	OMIM: 609134; MGI: 1861099; HomoloGene: 26151; GeneCards: UBR2; OMA:UBR2 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.1 Start 42,564,029 bp[1] End 42,693,505 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 C Start 47,239,221 bp[2] End 47,321,482 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte endothelial cell biceps brachii Skeletal muscle tissue of biceps brachii vastus lateralis muscle skin of hip hair follicle Skeletal muscle tissue of rectus abdominis Brodmann area 23 deltoid muscle Top expressed in Rostral migratory stream interventricular septum lacrimal gland ciliary body muscle of thigh submandibular gland vestibular membrane of cochlear duct retinal pigment epithelium neural layer of retina extraocular muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding zinc ion binding leucine binding ubiquitin protein ligase activity metal ion binding ubiquitin-protein transferase activity transferase activity Cellular component chromatin nucleus ubiquitin ligase complex cytoplasm cytosol Biological process cellular response to leucine protein catabolic process male meiosis I ubiquitin-dependent protein catabolic process protein ubiquitination ubiquitin-dependent protein catabolic process via the N-end rule pathway negative regulation of TOR signaling histone H2A ubiquitination protein polyubiquitination reciprocal meiotic recombination male meiotic nuclear division spermatogenesis negative regulation of transposition Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23304 224826 Ensembl ENSG00000024048 ENSMUSG00000023977 UniProt Q8IWV8 Q6WKZ8 RefSeq (mRNA) NM_001184801 NM_015255 NM_001363705 NM_001177374 NM_146078 RefSeq (protein) NP_001171730 NP_056070 NP_001350634 NP_001170845 NP_666190 Location (UCSC) Chr 6: 42.56 – 42.69 Mb Chr 17: 47.24 – 47.32 Mb PubMed search [3] [4]
Wikidata
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Proteolysis by the ubiquitin-proteasome system controls the concentration of many regulatory proteins. The selectivity of ubiquitylation is determined by ubiquitin E3 ligases, which recognize the substrate's destabilization signal, or degron. The E3 ligase UBR2 participates in the N-end rule pathway, which targets proteins bearing an N-terminal degron, or N-degron (Kwon et al., 2003).[supplied by OMIM]^[5]