UDP-glucose—hexose-1-phosphate uridylyltransferase

In enzymology, an UDP-glucose—hexose-1-phosphate uridylyltransferase (EC 2.7.7.12) is an enzyme that catalyzes the chemical reaction

UDP-glucose + alpha-D-galactose 1-phosphate ${\displaystyle \rightleftharpoons }$ alpha-D-glucose 1-phosphate + UDP-galactose

UDP-glucose:hexose-1-phosphate uridylyltransferase
Galactose-1-phosphate uridylyltransferase homodimer, Human
Identifiers
EC no.	2.7.7.12
CAS no.	9026-21-5
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Thus, the two substrates of this enzyme are UDP-glucose and alpha-D-galactose 1-phosphate, whereas its two products are alpha-D-glucose 1-phosphate and UDP-galactose.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is UDP-glucose:alpha-D-galactose-1-phosphate uridylyltransferase. Other names in common use include uridyl transferase, hexose-1-phosphate uridylyltransferase, uridyltransferase, and hexose 1-phosphate uridyltransferase. This enzyme participates in galactose metabolism and nucleotide sugars metabolism.

Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1HXQ, 2H39, 2Q4H, and 2Q4L.