Urea carboxylase

In enzymology, a urea carboxylase (EC 6.3.4.6) is an enzyme that catalyzes the chemical reaction

ATP + urea + HCO₃- ${\displaystyle \rightleftharpoons }$ ADP + phosphate + urea-1-carboxylate

urea carboxylase
Identifiers
EC no.	6.3.4.6
CAS no.	9058-98-4
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The 3 substrates of this enzyme are ATP, urea, and HCO3-, whereas its 3 products are ADP, phosphate, and urea-1-carboxylate (allophanate).

This enzyme belongs to the family of ligases, specifically those forming generic carbon-nitrogen bonds. The systematic name of this enzyme class is urea:carbon-dioxide ligase (ADP-forming). This enzyme participates in urea cycle and metabolism of amino groups. It employs one cofactor, biotin.

See also

• Allophanate hydrolase