Ureidoglycolate dehydrogenase

In enzymology, an ureidoglycolate dehydrogenase (EC 1.1.1.154) is an enzyme that catalyzes the chemical reaction

(S)-ureidoglycolate + NAD(P)⁺ ${\displaystyle \rightleftharpoons }$ oxalurate + NAD(P)H + H⁺

ureidoglycolate dehydrogenase
Identifiers
EC no.	1.1.1.154
CAS no.	62213-62-1
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The 3 substrates of this enzyme are (S)-ureidoglycolate, NAD⁺, and NADP⁺, whereas its 4 products are oxalurate, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is (S)-ureidoglycolate:NAD(P)⁺ oxidoreductase. This enzyme participates in purine metabolism.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1WTJ and 1XRH.