Valine dehydrogenase (NADP+)

In enzymology, a valine dehydrogenase (NADP⁺) (EC 1.4.1.8) is an enzyme that catalyzes the chemical reaction

L-valine + H₂O + NADP⁺ ${\displaystyle \rightleftharpoons }$ 3-methyl-2-oxobutanoate + NH₃ + NADPH + H⁺

valine dehydrogenase (NADP)
Identifiers
EC no.	1.4.1.8
CAS no.	37255-39-3
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The 3 substrates of this enzyme are L-valine, H₂O, and NADP⁺, whereas its 4 products are 3-methyl-2-oxobutanoate, NH₃, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH₂ group of donors with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is L-valine:NADP⁺ oxidoreductase (deaminating). Other names in common use include valine dehydrogenase (nicotinamide adenine dinucleotide phosphate), and valine dehydrogenase (NADP⁺).