Vellosimine dehydrogenase

In enzymology, a vellosimine dehydrogenase (EC 1.1.1.273) is an enzyme that catalyzes the chemical reaction

10-deoxysarpagine + NADP⁺ ${\displaystyle \rightleftharpoons }$ vellosimine + NADPH + H⁺

vellosimine dehydrogenase
Identifiers
EC no.	1.1.1.273
CAS no.	86777-26-6
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Thus, the two substrates of this enzyme are 10-deoxysarpagine and NADP⁺, whereas its 3 products are vellosimine, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is 10-deoxysarpagine:NADP⁺ oxidoreductase. This enzyme participates in indole and ipecac alkaloid biosynthesis.