Vesicular transport protein

A vesicular transport protein, or vesicular transporter, is a membrane protein that regulates or facilitates the movement of specific molecules across a vesicle's membrane.^[1] As a result, vesicular transporters govern the concentration of molecules within a vesicle.

Crystal structure of the vesicular transport protein

Types

Examples include:

• Archain
• ARFs
• Clathrin
• Caveolin
• Dynamin and related proteins, such as the EHD protein family
• Rab proteins
• SNAREs
• Vesicular transport adaptor proteins e.g. Sorting nexins
• Synaptotagmin
• TRAPP complex
• Synaptophysin
• Auxilin

Pathways

There are multiple pathways, each using its own coat and GTPase.^[2]

• COP 1 (Cytosolic coat protein complex ) : retrograde transport; Golgi ----> Endoplasmic reticulum
• COP 2 (Cytosolic coat protein complex ) : anterograde transport; RER -----> cis-Golgi
• Clathrin : trans-Golgi ----> Lysosomes, Plasma membrane ----> Endosomes (receptor-mediated endocytosis)

See also

• Membrane transport protein
• Wikipedia:MeSH D12.776#MeSH D12.776.543.990 --- vesicular transport proteins