Vitamin-K-epoxide reductase (warfarin-insensitive)

In enzymology, a vitamin-K-epoxide reductase (warfarin-insensitive) (EC 1.17.4.5) is an enzyme that catalyzes the chemical reaction

3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol ${\displaystyle \rightleftharpoons }$ 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol

vitamin-K-epoxide reductase (warfarin-insensitive)
Identifiers
EC no.	1.17.4.5
CAS no.	97089-80-0
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Thus, the two substrates of this enzyme are 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone and oxidized dithiothreitol, whereas its two products are 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone and 1,4-dithiothreitol.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH or CH2 groups of donor with a disulfide as acceptor. The systematic name of this enzyme class is 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone:oxidized-dithi othreitol oxidoreductase.