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Wells score (pulmonary embolism)
Estimates probability of pulmonary embolism From Wikipedia, the free encyclopedia
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The Wells score is a clinical prediction rule used to classify patients suspected of having pulmonary embolism (PE) into risk groups by quantifying the pre-test probability. It is different than Wells score for DVT (deep vein thrombosis). It was originally described by Wells et al. in 1998,[1] using their experience from creating Wells score for DVT in 1995.[2] Today, there are multiple (revised or simplified) versions of the rule, which may lead to ambiguity.[1][3][4]
The purpose of the rule is to select the best method of investigation (e.g. D-dimer testing, CT angiography) for ruling in or ruling out the diagnosis of PE, and to improve the interpretation and accuracy of subsequent testing, based on a Bayesian framework for the probability of the diagnosis.
The rule is more objective than clinician gestalt, but still includes subjective opinion (unlike e.g. Geneva score).
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Original algorithm[1]
Originally it was developed in 1998 to improve the low specificity of V/Q scan results (which then had a more important role in the workup of PE than now).
It categorized patients into 3 categories: low / moderate / high probability. It was formulated in the form of an algorithm, not a score.
Subsequent testing choices were V/Q scanning, pulmonary angiography, and serial compression ultrasound.
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Revised score [3][4]
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This section needs expansion. You can help by adding to it. Find sources: "pulmonary embolism" – news · newspapers · books · scholar · JSTOR (November 2022) |
The emergence of rapid D-dimer assays in 1995[5] prompted revision of the rule. The D-dimer assay and the revised Wells score can be combined to identify a population with a pre-test probability of PE of less than 2%.[6]
This version was published as a score, and according to the final score, patients could be categorized in either 3 groups (low / intermediate / high risk) or 2 groups (PE unlikely/ PE likely).
Subsequent testing choices included D-dimer testing for low risk cases to further understand the pre-test probability; and V/Q scanning, pulmonary angiography, and compression ultrasonography for intermediate / high risk patients and low-risk patients with positive D-dimer results.
Risk of PE using 3 categories (data from the derivation group)
Risk of PE using 2 categories (data from the derivation group)
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References
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