Xylosylprotein 4-beta-galactosyltransferase

In enzymology, a xylosylprotein 4-beta-galactosyltransferase (EC 2.4.1.133) is an enzyme that catalyzes the chemical reaction

UDP-galactose + O-beta-D-xylosylprotein ${\displaystyle \rightleftharpoons }$ UDP + 4-beta-D-galactosyl-O-beta-D-xylosylprotein

xylosylprotein 4-beta-galactosyltransferase
Identifiers
EC no.	2.4.1.133
CAS no.	52227-72-2
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Thus, the two substrates of this enzyme are UDP-galactose and O-beta-D-xylosylprotein, whereas its two products are UDP and 4-beta-D-galactosyl-O-beta-D-xylosylprotein.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-galactose:O-beta-D-xylosylprotein 4-beta-D-galactosyltransferase. Other names in common use include UDP-D-galactose:D-xylose galactosyltransferase, UDP-D-galactose:xylose galactosyltransferase, galactosyltransferase I, and uridine diphosphogalactose-xylose galactosyltransferase. This enzyme participates in chondroitin sulfate biosynthesis and glycan structures - biosynthesis 1. It employs one cofactor, manganese.