YdaO/yuaA leader

The YdaO/YuaA leader (now called the cyclic di-AMP riboswitch) is a conserved RNA structure found upstream of the ydaO and yuaA genes in Bacillus subtilis and related genes in other bacteria. Its secondary structure and gene associations were predicted by bioinformatics.^[1]

ydaO/yuaA leader
Predicted secondary structure and sequence conservation of ydaO-yuaA
Identifiers
Symbol	ydaO-yuaA
Rfam	RF00379
Other data
RNA type	Cis-reg; riboswitch
Domain(s)	Bacteria
SO	SO:0000233
PDB structures	PDBe

These RNAs function as riboswitches, and sense the signaling molecule cyclic di-AMP.^[2] The interaction between the riboswitch and c-di-AMP has been revealed in atomic-resolution structures.^[3][4][5]