Aceperone

Aceperone is a neuroleptic drug of the butyrophenone class. It is an α-noradrenergic blocking drug developed by Janssen Pharmaceutica in the 1960s.^[1]

Aceperone

Clinical data
Other names	Acetabuton; R 3248
ATC code	none
Identifiers
IUPAC name N-({1-[4-(4-Fluorophenyl)-4-oxobutyl]-4-phenyl-4-piperidinyl}methyl)acetamide
CAS Number	807-31-8
PubChem CID	13122
ChemSpider	12570
UNII	S69KXZ59AB
ChEMBL	ChEMBL136298
CompTox Dashboard (EPA)	DTXSID30230510
Chemical and physical data
Formula	C24H29FN2O2
Molar mass	396.506 g·mol−1
3D model (JSmol)	Interactive image
Melting point	97 to 100 °C (207 to 212 °F) [1]
SMILES Fc1ccc(cc1)C(=O)CCCN3CCC(c2ccccc2)(CC3)CNC(=O)C
InChI InChI=1S/C24H29FN2O2/c1-19(28)26-18-24(21-6-3-2-4-7-21)13-16-27(17-14-24)15-5-8-23(29)20-9-11-22(25)12-10-20/h2-4,6-7,9-12H,5,8,13-18H2,1H3,(H,26,28) Key:VDGZERMDPAAZEJ-UHFFFAOYSA-N

Aceperone has been used as a tool in the study of the biochemical basis of learning. Although aceperone does not block learning per se, it blocks access to an attentional mechanism by which animals ‘tune in’ to the relevant visual dimension when learning a visual discrimination task^[2][3] at doses below those that affect general behaviour.^[4]