Thienotriazolodiazepine

Not to be confused with thienobenzodiazepine or thienodiazepine.

A thienotriazolodiazepine^[1] is a heterocyclic compound containing a diazepine ring fused to thiophene and triazole rings. Thienotriazolodiazepine forms the central core of several pharmaceutical drugs including:

• α-Hydroxyetizolam
• Brotizolam
• Ciclotizolam
• Clotizolam
• Deschloroclotizolam
• Deschloroetizolam
• Etizolam
• Flubrotizolam
• Fluclotizolam
• Fluetizolam
• Metizolam

Core structure of thienotriazolodiazepines

Thienotriazolodiazepines interact with the benzodiazepine receptor site, they typically have similar effects as 1,4-benzodiazepines (such as diazepam) and triazolobenzodiazepines (such as alprazolam).

Thienotriazolodiazepines that are not GABA_A receptor positive allosteric modulators include:

• Apafant
• Israpafant^[2]
• JQ1