Chromatin bridge
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Chromatin bridge is a mitotic occurrence that forms when telomeres of sister chromatids fuse together and fail to completely segregate into their respective daughter cells. Because this event is most prevalent during anaphase, the term anaphase bridge is often used as a substitute. After the formation of individual daughter cells, the DNA bridge connecting homologous chromosomes remains fixed. As the daughter cells exit mitosis and re-enter interphase, the chromatin bridge becomes known as an interphase bridge. These phenomena are usually visualized using the laboratory techniques of staining and fluorescence microscopy.[1][2]
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Chromatin bridge | |
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DAPI staining allows for visualization of deoxyribonucleic acid portions of the two daughter cells. The thin “string-like” DNA connecting them is defined as a chromatin bridge. | |
Specialty | Pathology |
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