Denosumab
Human monoclonal antibody / From Wikipedia, the free encyclopedia
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Denosumab, sold under the brand names Prolia and Xgeva among others, is a human monoclonal antibody used for the treatment of osteoporosis, treatment-induced bone loss, metastases to bone, and giant cell tumor of bone.[7][8]
Quick Facts Monoclonal antibody, Type ...
Monoclonal antibody | |
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Type | Whole antibody |
Source | Human |
Target | RANK ligand |
Clinical data | |
Trade names | Prolia, Xgeva, others |
Other names | AMG-162 |
Biosimilars | denosumab-bbdz, Jubbonti,[1] Wyost[2] |
AHFS/Drugs.com | Monograph |
MedlinePlus | a610023 |
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Routes of administration | Subcutaneous |
ATC code | |
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Pharmacokinetic data | |
Bioavailability | N/A |
Metabolism | Proteolysis |
Identifiers | |
CAS Number | |
DrugBank |
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ChemSpider |
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Chemical and physical data | |
Formula | C6404H9912N1724O2004S50 |
Molar mass | 144722.80 g·mol−1 |
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Denosumab is contraindicated in people with low blood calcium levels. The most common side effects are joint and muscle pain in the arms or legs.[9]
Denosumab is an inhibitor of RANKL (receptor activator of nuclear factor kappa-Β ligand),[7] which works by decreasing the development of osteoclasts, which are cells that break down bone. It was developed by the biotechnology company Amgen.[10]