See also: esn English Noun ESN (plural ESNs) Initialism of electronic serial number. (computing) Initialism of echo state network. Adjective ESN (not comparable) Initialism of educationally subnormal. Anagrams ENS, Ens., NES, SEN, SNe, Sen, Sen., ens, senWikiwand - on Seamless Wikipedia browsing. On steroids.Remove ads