FLS

English

Noun

FLS (countable and uncountable, plural FLSs)

1. Initialism of Frontline State.
2. (cytology) Initialism of fibroblast-like synoviocyte.
   • 2019 July 8, Michael Bonelli, Karolina Dalwigk, Alexander Platzer, Isabel Olmos Calvo, Silvia Hayer, Birgit Niederreiter, et al., “IRF1 is critical for the TNF-driven interferon response in rheumatoid fibroblast-like synoviocytes”, in Experimental & Molecular Medicine, volume 51, →DOI, page 1:

     The major drivers of synovial inflammation are cytokines and chemokines. Among these molecules, TNF activates fibroblast-like synoviocytes (FLSs), which leads to the production of inflammatory mediators. Here, we show that TNF regulates the expression of the transcription factor interferon regulatory factor 1 (IRF1) in human FLSs as well as in a TNF transgenic arthritis mouse model.