Loxapine
Antipsychotic medication / From Wikipedia, the free encyclopedia
Dear Wikiwand AI, let's keep it short by simply answering these key questions:
Can you list the top facts and stats about loxapine?
Summarize this article for a 10 year old
SHOW ALL QUESTIONS
Loxapine, sold under the brand names Loxitane and Adasuve (inhalation only) among others, is a tricyclic[4] antipsychotic medication used primarily in the treatment of schizophrenia. The medicine is a member of the dibenzoxazepine class and structurally very similar to clozapine. Several researchers have argued that loxapine, initially classified as a typical antipsychotic, behaves as an atypical antipsychotic.[5]
Quick Facts Clinical data, Trade names ...
Clinical data | |
---|---|
Trade names | Loxitane, Adasuve |
AHFS/Drugs.com | Monograph |
MedlinePlus | a682311 |
License data | |
Routes of administration | By mouth, inhalation, intramuscular |
Drug class | Antipsychotic |
ATC code | |
Legal status | |
Legal status | |
Pharmacokinetic data | |
Protein binding | 96.8%[3] |
Metabolism | Extensive Liver; active metabolites include amoxapine and 8-hydroxyloxapine. Inhibits P-gp and is a substrate of CYP1A2, CYP3A4 and CYP2D6[3] |
Elimination half-life | 4 hours (oral); 7.61 hours (inhalation)[3] |
Excretion | Majority are excreted within 24 hours, main route through urine (conjugated metabolites), small amounts through the feces (unconjugated metabolites) |
Identifiers | |
| |
CAS Number | |
PubChem CID | |
IUPHAR/BPS | |
DrugBank |
|
ChemSpider |
|
UNII | |
KEGG |
|
ChEBI | |
ChEMBL | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.016.215 |
Chemical and physical data | |
Formula | C18H18ClN3O |
Molar mass | 327.81 g·mol−1 |
3D model (JSmol) | |
Melting point | 109 to 110 °C (228 to 230 °F) |
| |
| |
NY (what is this?) (verify) |
Close
Loxapine may be metabolized by N-demethylation to amoxapine, a tricyclic antidepressant.[6]