The 2021 Open 13 Provence was a men's tennis tournament played on indoor hard courts. It is the 29th edition of the Open 13, and part of the ATP Tour 250 series of the 2021 ATP Tour. It was the 29th edition of the tournament and took place at the Palais des Sports in Marseille, France, from 8 March until 14 March 2021. First-seeded Daniil Medvedev won the singles title.