Agrinio is the largest city of the Aetolia-Acarnania regional unit of Greece and its largest municipality, with 89,691 inhabitants (2021) as well as the second largest city in Western Greece after Patras. It is the economic center of Aetolia-Acarnania, although its capital is the town of Mesolonghi. The settlement dates back to ancient times. Ancient Agrinion was 3 kilometres northeast of the present city; some walls and foundations of which have been excavated. In medieval times and until 1836, the city was known as Vrachori (Βραχώρι).