The Cali Cartel was a drug cartel based in southern Colombia, around Cali and the Valle del Cauca. Its founders were the brothers Gilberto Rodríguez Orejuela, Miguel Rodríguez Orejuela and José Santacruz Londoño. They broke away from Pablo Escobar and his Medellín associates in 1988, when Hélmer Herrera joined what became a four-man executive board that ran the cartel.