Castelpizzuto is a comune (municipality) in the Province of Isernia in the Italian region Molise, located about 30 kilometres (19 mi) west of Campobasso and about 11 kilometres (7 mi) southeast of Isernia. As of 31 December 2004, it had a population of 156 and an area of 15.2 square kilometres (5.9 sq mi).