Drury Run is a tributary of the West Branch Susquehanna River in Clinton County, Pennsylvania, in the United States. It is 7.71 miles (12.41 km) long and its watershed is 11.5 square miles in area, most of which is forest. The stream's tributaries are affected by acid mine drainage, as are the lower reaches of the stream itself. It begins in Tamarack Swamp and flows through Leidy Township, Noyes Township, and Renovo. Brook trout, brown trout, creek chub, and eastern blacknose dace all inhabit the stream.