Espy Run is a tributary of Nanticoke Creek in Luzerne County, Pennsylvania, in the United States. It is approximately 2.4 miles (3.9 km) long and flows through Nanticoke and Hanover Township. The watershed of the stream has an area of 3.14 square miles (8.1 km2). The stream is affected by abandoned mine drainage and has been affected by sewage in the past. The Espy Run Wetlands and the Espy Run discharge are in the stream's vicinity. The surficial geology in the area consists of urban land, coal dumps, surface mining land, Wisconsinan Till, Wisconsinan Ice-Contact Stratified Drift, and bedrock.