The First Callahan Building is an historic commercial and residential building at 276 Lisbon Street in Lewiston, Maine. Built in 1892 to a design by noted local architect George M. Coombs, the Renaissance Revival brick building was part of a major development on the city's main commercial street by the Callahan brothers, owners of a local gentleman's furnishings store. The building was listed on the National Register of Historic Places in 1986.