Gay Street is a street in Knoxville, Tennessee, United States, that traverses the heart of the city's downtown area. Since its development in the 1790s, Gay Street has served as the city's principal financial and commercial thoroughfare, and has played a primary role in the city's historical and cultural development. The street contains Knoxville's largest office buildings and oldest commercial structures. Several buildings on Gay Street have been listed on the National Register of Historic Places.