Interstate 5 (I-5) in the U.S. state of Oregon is a major Interstate Highway that traverses the state from north to south. It travels to the west of the Cascade Mountains, connecting Portland to Salem, Eugene, Medford, and other major cities in the Willamette Valley and across the northern Siskiyou Mountains. The highway runs 308 miles (496 km) from the California state line near Ashland to the Washington state line in northern Portland, forming the central part of Interstate 5's route between Mexico and Canada.