The Society of Jesus, also known as the Jesuit Order or the Jesuits, is a religious order of clerics regular of pontifical right for men in the Catholic Church headquartered in Rome. It was founded in 1540 by Ignatius of Loyola and six companions, with the approval of Pope Paul III. The Society of Jesus is the largest religious order in the Catholic Church and has played a significant role in education, charity, humanitarian acts and global policies. The Society of Jesus is engaged in evangelization and apostolic ministry in 112 countries. Jesuits work in education, research, and cultural pursuits. They also conduct retreats, minister in hospitals and parishes, sponsor direct social and humanitarian works, and promote ecumenical dialogue.