Manuel Komnenos was the eldest son of Byzantine emperor Andronikos I Komnenos, and the progenitor of the Grand Komnenos dynasty of the Empire of Trebizond. He served his uncle, Manuel I Komnenos, as a diplomatic envoy to the Russian principalities and the Kingdom of Jerusalem, but also helped his father escape imprisonment in Constantinople. His opposition to the regency of Empress-dowager Maria of Antioch and the protosebastos Alexios Komnenos landed him in prison, but he was released in April 1182, when his father stood poised to take power in the Byzantine capital.