The Space Shuttle program was the fourth human spaceflight program carried out by the U.S. National Aeronautics and Space Administration (NASA), which accomplished routine transportation for Earth-to-orbit crew and cargo from 1981 to 2011. Its official program name was Space Transportation System (STS), taken from a 1969 plan for a system of reusable spacecraft where it was the only item funded for development, as a proposed nuclear shuttle in the plan was cancelled in 1972. It flew 135 missions and carried 355 astronauts from 16 countries, many on multiple trips.