Thirkleby High and Low with Osgodby is a civil parish in North Yorkshire, England. The parish includes the villages of Great Thirkleby and Little Thirkleby and the scattered hamlet of Osgodby. The similarly named medieval settlement of Thirkleby Manor is around 30 miles north, in the parish of Kirby Grindalythe. The population of the civil parish taken at the 2011 Census was 266.