The Wolf River is a river in Harrison, Hancock and Pearl River counties, Mississippi, in the United States. Wolf Creek and Mill Creek merge into Wolf River in Hillsdale, Mississippi. It passes the Wolf River Game Management Area. The river also passes through the Wolf River Marsh Coastal Preserve. The preserve is home to nine endangered species and the boundary of the preserve is located in Harrison County. It is home to a non-forested marsh along the Wolf River from Grassy Point to where the marsh ends. Wolf River discharges at the Bay of St. Louis which is known as Dimitry Point and the region is known as Alexander Dimitry Claim.