3-ヒドロキシアシルCoAデヒドロゲナーゼ

3-ヒドロキシアシルCoAデヒドロゲナーゼ（3-hydroxyacyl-CoA dehydrogenase）は、次の化学反応を触媒する酸化還元酵素である。

(S)-3-ヒドロキシアシルCoA + NAD⁺ ${\displaystyle \rightleftharpoons }$ 3-オキソアシルCoA + NADH + H⁺

3-ヒドロキシアシルCoAデヒドロゲナーゼ
識別子
EC番号	1.1.1.35
CAS登録番号	9028-40-4
データベース
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB構造	RCSB PDB PDBj PDBe PDBsum
遺伝子オントロジー	AmiGO / QuickGO
検索 PMC articles PubMed articles NCBI proteins

反応式の通り、この酵素の基質は(S)-3-ヒドロキシアシルCoAとNAD⁺、生成物は3-オキソアシルCoAとNADHとH⁺である。

組織名は(S)-3-hydroxyacyl-CoA:NAD⁺ oxidoreductaseで、別名にβ-hydroxyacyl dehydrogenase, β-keto-reductase, 3-keto reductase, 3-hydroxyacyl coenzyme A dehydrogenase, β-hydroxyacyl-coenzyme A synthetase, β-hydroxyacylcoenzyme A dehydrogenase, β-hydroxybutyrylcoenzyme A dehydrogenase, 3-hydroxyacetyl-coenzyme A dehydrogenase, L-3-hydroxyacyl coenzyme A dehydrogenase, L-3-hydroxyacyl CoA dehydrogenase, β-hydroxyacyl CoA dehydrogenase, β-hydroxyacyl coenzyme A dehydrogenase, 3-hydroxybutyryl-CoA dehydrogenase, β-ketoacyl-CoA reductase, β-hydroxy acid dehydrogenase, 3-L-hydroxyacyl-CoA dehydrogenase, 3-hydroxyisobutyryl-CoA dehydrogenase, 1-specific DPN-linked beta-hydroxybutyric dehydrogenaseがある。

参考文献

• Hillmer P and Gottschalk G (1974). “Solubilization and partial characterisation of particulate dehydrogenases from Clostridium kluyveri”. Biochim. Biophys. Acta 334: 12–23.
• LEHNINGER AL, GREVILLE GD (1953). “The enzymic oxidation of alpha- and 2-beta-hydroxybutyrate”. Biochim. Biophys. Acta. 12: 188–202. doi:10.1016/0006-3002(53)90138-3. PMID 13115428.
• Stern JR (1957). “Crystalline beta-hydroxybutyrate dehydrogenase from pig heart”. Biochim. Biophys. Acta 26: 448–449. doi:10.1016/0006-3002(57)90040-9.
• Wakil SJ, Green DE, Mii S and Mahler HR (1954). “Studies on the fatty acid oxidizing system of animal tissues. VI beta-Hydroxyacyl coenzyme A dehydrogenase”. J. Biol. Chem. 207: 631–638.