L-リシン-6-モノオキシゲナーゼ (NADPH)

L-リシン-6-モノオキシゲナーゼ (NADPH)（L-lysine 6-monooxygenase (NADPH)）は、リシン分解酵素の一つで、次の化学反応を触媒する酸化還元酵素である。

L-リシン + NADPH + H⁺ + O₂ ${\displaystyle \rightleftharpoons }$ N⁶-ヒドロキシ-L-リシン + NADP⁺ + H₂O

L-リシン-6-モノオキシゲナーゼ (NADPH)
識別子
EC番号	1.14.13.59
CAS登録番号	64295-82-5
データベース
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB構造	RCSB PDB PDBj PDBe PDBsum
遺伝子オントロジー	AmiGO / QuickGO
検索 PMC articles PubMed articles NCBI proteins

この酵素の基質はL-リシン、NADPH、H⁺とO₂で、生成物はN⁶-ヒドロキシ-L-リシン、NADP⁺とH₂Oである。

組織名はL-lysine,NADPH:oxygen oxidoreductase (6-hydroxylating)で、別名にlysine N⁶-hydroxylaseがある。

参考文献

• Plattner HJ, Pfefferle P, Romaguera A, Waschutza S, Diekmann H (1989). “Isolation and some properties of lysine N6-hydroxylase from Escherichia coli strain EN222”. Biol. Met. 2 (1): 1–5. doi:10.1007/BF01116193. PMID 2518519.
• Macheroux P, Plattner HJ, Romaguera A, Diekmann H (1993). “FAD and substrate analogs as probes for lysine N6-hydroxylase from Escherichia coli EN 222”. Eur. J. Biochem. 213 (3): 995–1002. doi:10.1111/j.1432-1033.1993.tb17846.x. PMID 8504838.
• Thariath AM, Fatum KL, Valvano MA, Viswanatha T (1993). “Physico-chemical characterization of a recombinant cytoplasmic form of lysine: N6-hydroxylase”. Biochim. Biophys. Acta. 1203 (1): 27–35. PMID 8218389.
• de Lorenzo V, Bindereif A, Paw BH, Neilands JB (1986). “Aerobactin biosynthesis and transport genes of plasmid ColV-K30 in Escherichia coli K-12”. J. Bacteriol. 165 (2): 570–8. PMC 214457. PMID 2935523. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC214457/.
• Marrone L, Siemann S, Beecroft M and Viswanatha T (1996). “Specificity of lysine:N-6-hydroxylase: A hypothesis for a reactive substrate intermediate in the catalytic mechanism”. Bioorg. Chem. 24: 401–406. doi:10.1006/bioo.1996.0034.
• Goh CJ, Szczepan EW, Menhart N, Viswanatha T (1989). “Studies on lysine:N6-hydroxylation by cell-free systems of Aerobacter aerogenes 62-1”. Biochim. Biophys. Acta. 990 (3): 240–5. PMID 2493814.