알프레드 G. 길먼

알프레드 굿맨 길먼(영어: Alfred Goodman Gilman, 1941년 7월 1일 ~ 2015년 12월 23일)은 미국의 생화학자, 약리학자^[1]이다. 1994년에 세포막에 존재하는 G단백질을 발견한 공로로 마틴 로드벨과 함께 노벨 생리학·의학상을 수상했다.^[2]

알프레드 G. 길먼 Alfred G. Gilman
1994년 촬영
출생	1941년 7월 1일(1941-07-01) 미국 코네티컷주 뉴헤이븐
사망	2015년 12월 23일(2015-12-23)(74세) 미국 텍사스주 댈러스
국적	미국
출신 학교	예일 대학교 케이스 웨스턴 리저브 대학교
주요 업적	G단백질
수상	John J. Abel Award(1975년) 리처드 런즈베리상(1987년) 루이자 그로스 호르위츠상(1989년) 노벨 생리학·의학상(1994년)
분야	생화학, 약리학

수상 경력

• 1975년 : John J. Abel Award
• 1984년 : 가드너 국제상
• 1987년 : 리처드 런즈베리상
• 1989년 : 루이자 그로스 호르위츠상
• 1989년 : 앨버트 래스커 기초 의학 연구상
• 1994년 : 노벨 생리학·의학상

주요 논문

• Seeds, NW; Gilman, AG (1971). “Norepinephrine stinulated increase of cyclic AMP levels in developing mouse brain cell cultures”. 《Science》 174 (4006): 292. doi:10.1126/science.174.4006.292. PMID 4330303.
• Gilman, AG; Nirenberg, M (1971). “Regulation of adenosine 3',5'-cyclic monophosphate metabolism in cultured neuroblastoma cells”. 《Nature》 234 (5328): 356–8. doi:10.1038/234356a0. PMID 4332686.
• Secrist JA, 3rd; Barrio, JR; Leonard, NJ; Villar-Palasi, C; Gilman, AG (1972). “Fluorescent modification of adenosine 3',5'-monophosphate: spectroscopic properties and activity in enzyme systems”. 《Science》 177 (4045): 279–80. doi:10.1126/science.177.4045.279. PMID 4339302.
• Sternweis, PC; Northup, JK; Smigel, MD; Gilman, AG (1981). “The regulatory component of adenylate cyclase. Purification and properties”. 《The Journal of Biological Chemistry》 256 (22): 11517–26. PMID 6271754.
• Hanski, E; Sternweis, PC; Northup, JK; Dromerick, AW; Gilman, AG (1981). “The regulatory component of adenylate cyclase. Purification and properties of the turkey erythrocyte protein”. 《The Journal of Biological Chemistry》 256 (24): 12911–9. PMID 6273414.
• Schleifer, LS; Kahn, RA; Hanski, E; Northup, JK; Sternweis, PC; Gilman, AG (1982). “Requirements for cholera toxin-dependent ADP-ribosylation of the purified regulatory component of adenylate cyclase”. 《The Journal of Biological Chemistry》 257 (1): 20–3. PMID 6273425.
• Northup, JK; Smigel, MD; Gilman, AG (1982). “The guanine nucleotide activating site of the regulatory component of adenylate cyclase. Identification by ligand binding”. 《The Journal of Biological Chemistry》 257 (19): 11416–23. PMID 6288684.
• Manning, DR; Gilman, AG (1983). “The regulatory components of adenylate cyclase and transducin. A family of structurally homologous guanine nucleotide-binding proteins”. 《The Journal of Biological Chemistry》 258 (11): 7059–63. PMID 6304074.
• Northup, JK; Sternweis, PC; Gilman, AG (1983). “The subunits of the stimulatory regulatory component of adenylate cyclase. Resolution, activity, and properties of the 35,000-dalton (beta) subunit”. 《The Journal of Biological Chemistry》 258 (18): 11361–8. PMID 6309843.
• Northup, JK; Smigel, MD; Sternweis, PC; Gilman, AG (1983). “The subunits of the stimulatory regulatory component of adenylate cyclase. Resolution of the activated 45,000-dalton (alpha) subunit”. 《The Journal of Biological Chemistry》 258 (18): 11369–76. PMID 6309844.
• Hurley, JB; Simon, MI; Teplow, DB; Robishaw, JD; Gilman, AG (1984). “Homologies between signal transducing G proteins and ras gene products”. 《Science》 226 (4676): 860–2. doi:10.1126/science.6436980. PMID 6436980.
• Gilman, AG (1984). “G proteins and dual control of adenylate cyclase”. 《Cell》 36 (3): 577–9. doi:10.1016/0092-8674(84)90336-2. PMID 6321035.
• Bokoch, GM; Gilman, AG (1984). “Inhibition of receptor-mediated release of arachidonic acid by pertussis toxin”. 《Cell》 39 (2 Pt 1): 301–8. doi:10.1016/0092-8674(84)90008-4. PMID 6094010.
• Harris, BA; Robishaw, JD; Mumby, SM; Gilman, AG (1985). “Molecular cloning of complementary DNA for the alpha subunit of the G protein that stimulates adenylate cyclase”. 《Science》 229 (4719): 1274–7. doi:10.1126/science.3839937. PMID 3839937.
• Mattera, R; Graziano, MP; Yatani, A; Zhou, Z; Graf, R; Codina, J; Birnbaumer, L; Gilman, AG; Brown, AM (1989). “Splice variants of the alpha subunit of the G protein Gs activate both adenylyl cyclase and calcium channels”. 《Science》 243 (4892): 804–7. doi:10.1126/science.2536957. PMID 2536957.
• Krupinski, J; Coussen, F; Bakalyar, HA; Tang, WJ; Feinstein, PG; Orth, K; Slaughter, C; Reed, RR; Gilman, AG (1989). “Adenylyl cyclase amino acid sequence: possible channel- or transporter-like structure”. 《Science》 244 (4912): 1558–64. doi:10.1126/science.2472670. PMID 2472670.
• Tang, WJ; Gilman, AG (1991). “Type-specific regulation of adenylyl cyclase by G protein beta gamma subunits”. 《Science》 254 (5037): 1500–3. doi:10.1126/science.1962211. PMID 1962211.
• Taussig, R; Iñiguez-Lluhi, JA; Gilman, AG (1993). “Inhibition of adenylyl cyclase by Gi alpha”. 《Science》 261 (5118): 218–21. doi:10.1126/science.8327893. PMID 8327893.
• Wickman, KD; Iñiguez-Lluhl, JA; Davenport, PA; Taussig, R; Krapivinsky, GB; Linder, ME; Gilman, AG; Clapham, DE (1994). “Recombinant G-protein beta gamma-subunits activate the muscarinic-gated atrial potassium channel”. 《Nature》 368 (6468): 255–7. doi:10.1038/368255a0. PMID 8145826.
• Coleman, D.; Berghuis, A.; Lee, E; Linder, M.; Gilman, A.; Sprang (1994). “Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis”. 《Science》 265 (5177): 1405–1412. doi:10.1126/science.8073283. PMID 8073283.
• Tang, WJ; Gilman, AG (1995). “Construction of a soluble adenylyl cyclase activated by Gs alpha and forskolin”. 《Science》 268 (5218): 1769–72. doi:10.1126/science.7792604. PMID 7792604.
• Mixon, MB; Lee, E; Coleman, DE; Berghuis, AM; Gilman, AG; Sprang, SR (1995). “Tertiary and quaternary structural changes in Gi alpha 1 induced by GTP hydrolysis”. 《Science》 270 (5238): 954–60. doi:10.1126/science.270.5238.954. PMID 7481799.
• Wall, MA; Coleman, DE; Lee, E; Iñiguez-Lluhi, JA; Posner, BA; Gilman, AG; Sprang, SR (1995). “The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2”. 《Cell》 83 (6): 1047–58. doi:10.1016/0092-8674(95)90220-1. PMID 8521505.
• Berman, David M; Wilkie, Thomas M; Gilman, Alfred G (1996). “GAIP and RGS4 Are GTPase-Activating Proteins for the Gi Subfamily of G Protein α Subunits”. 《Cell》 86 (3): 445–452. doi:10.1016/S0092-8674(00)80117-8. PMID 8756726.
• Sunahara, RK; Tesmer, JJ; Gilman, AG; Sprang, SR (1997). “Crystal structure of the adenylyl cyclase activator Gsalpha”. 《Science》 278 (5345): 1943–7. doi:10.1126/science.278.5345.1943. PMID 9395396.
• Tesmer, JJ; Sunahara, RK; Gilman, AG; Sprang, SR (1997). “Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS”. 《Science》 278 (5345): 1907–16. doi:10.1126/science.278.5345.1907. PMID 9417641.

참고 문헌

• “The crystal structure of β2-adrenergic receptor, a classic GPCR was at last revealed.”. 《Nature》 450: 355–356. doi:10.1038/450355a.
• “Authors' summary on the structure”. 《Science》 318.