Калцитонин

Калцитонин (или тирокалцитонин) е хормон кој се синтетизира од штитната жлезда, поточно од посебни клетки, наречени парафоликуларни клетки. Тој учествува во регулацијата на метаболизмот на калциум и фосфор. Калцитонинот стимулира вградување на калциум во коските и зголемување на концентрацијата на фосфор во крвта. Овој хормон има важна улога и во процесот на окоскувањето.

Калцитонин
Расположливи структури PDB Пребарување во Ortholog: PDBe RCSB List of PDB id codes 2JXZ,%%s1LS7
Назнаки
Алијаси	CALCA, CT, CGRP-I, CGRP-alpha, KC, PCT, calcitonin related polypeptide alpha, CGRP, CGRP1, CALC1
Надворешни назнаки	OMIM: 114130 MGI: 2151253 HomoloGene: 88401 GeneCards: CALCA
Место на генот (човечки) Хр. Chromosome 11 (human)[1] Појас 11p15.2 Почеток 14,966,668 bp[1] Крај 14,972,351 bp[1]
Место на генот (глушец) Хр. Chromosome 7 (mouse)[2] Појас 7 F1|7 59.99 cM Почеток 114,230,713 bp[2] Крај 114,235,592 bp[2]
Шема на РНК-експресија Bgee Човек Глушец (ортолог) Top expressed in spinal ganglia trigeminal ganglion quadriceps femoris muscle vastus lateralis muscle cerebellar vermis human kidney Epithelium of choroid plexus tibialis anterior muscle right lobe of liver Top expressed in facial motor nucleus motor neuron lumbar spinal ganglion anterior horn of spinal cord lactiferous gland trigeminal ganglion vestibular membrane of cochlear duct More reference expression data BioGPS More reference expression data
Генска онтологија Молекулска функција hormone activity calcitonin receptor binding protein binding identical protein binding signaling receptor binding protein-containing complex binding Клеточна составница Цитоплазма intracellular anatomical structure extracellular region живчено влакно terminal bouton soma neuron projection клеточно јадро extracellular space Биолошки процес cellular response to nerve growth factor stimulus positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway negative regulation of smooth muscle contraction regulation of heart contraction monocyte chemotaxis negative regulation of blood pressure positive regulation of cytosolic calcium ion concentration cellular response to tumor necrosis factor стареење вазодилатација cellular calcium ion homeostasis response to heat negative regulation of nervous system process positive regulation of ossification activation of adenylate cyclase activity regulation of heart rate detection of temperature stimulus involved in sensory perception of pain negative regulation of ossification response to pain artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure прехранбено поведение inflammatory response neuropeptide signaling pathway negative regulation of transcription, DNA-templated activation of protein kinase activity embryo implantation negative regulation of bone resorption regulation of signaling receptor activity G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway regulation of cytosolic calcium ion concentration leukocyte cell-cell adhesion G protein-coupled receptor internalization positive regulation of interleukin-1 alpha production response to yeast negative regulation of osteoclast differentiation cell-cell signaling antibacterial humoral response positive regulation of macrophage differentiation receptor internalization regulation of blood pressure protein phosphorylation vasculature development defense response to Gram-negative bacterium endothelial cell proliferation positive regulation of interleukin-8 production nervous system process involved in regulation of systemic arterial blood pressure negative regulation of calcium ion transport into cytosol Вроден имунолошки систем endothelial cell migration antifungal humoral response defense response to Gram-positive bacterium antimicrobial humoral immune response mediated by antimicrobial peptide amylin receptor signaling pathway calcitonin gene-related peptide receptor signaling pathway Извори:Amigo / QuickGO
Ортолози Вид Човек Глушец Entrez 796 12310 Ensembl ENSG00000110680 ENSMUSG00000030669 UniProt P06881 P70160 Q99JA0 RefSeq (mRNA) NM_001033952 NM_001033953 NM_001741 NM_001378949 NM_001378950 NM_001033954 NM_007587 NM_001289444 NM_001305616 RefSeq (белков.) NP_001029125.1 NP_001029126 NP_001276373 NP_001292545 NP_031613 NP_001029126.1 NP_001276373.1 Место (UCSC) Chr 11: 14.97 – 14.97 Mb Chr 7: 114.23 – 114.24 Mb Пребарување на PubMed [3] [4]
Википодатоци
Прегл./Уред. човечки Прегл./Уред. глувчешки