Catecol O-Metiltransferase

COMT
Estruturas disponíveis
PDB	Pesquisa Human UniProt: PDBe RCSB
Lista de códigos id do PDB
	4XUE, 3A7E, 3BWM, 3BWY, 4PYI, 4PYJ, 4PYK, 4XUC, 4XUD
Identificadores
Nomes alternativos	COMT
IDs externos	OMIM: 116790 HomoloGene: 30982 GeneCards: COMT
Targeted by Drug
	entacapone, tolcapona, Viroporin 3a
Ontologia genética
Função molecular	• transferase activity; • O-methyltransferase activity; • metal ion binding; • GO:0001948, GO:0016582 ligação a proteínas plasmáticas; • magnesium ion binding; • catechol O-methyltransferase activity; • GO:0102674, GO:0102675 methyltransferase activity; • L-dopa O-methyltransferase activity; • orcinol O-methyltransferase activity;
Componente celular	• citoplasma; • integral component of membrane; • corpo celular; • citosol; • postsynaptic membrane; • membrane; • membrana plasmática; • Espinha dendrítica; • axónio; • dendrito; • mitocôndria; • Exossoma; • intracellular membrane-bounded organelle;
Processo biológico	• multicellular organismal reproductive process; • negative regulation of smooth muscle cell proliferation; • GO:1904578 response to organic cyclic compound; • regulation of sensory perception of pain; • estrogen metabolic process; • cellular response to phosphate starvation; • catechol-containing compound metabolic process; • female pregnancy; • negative regulation of dopamine metabolic process; • GO:0007571 developmental process; • aprendizagem; • catecholamine metabolic process; • neurotransmitter catabolic process; • response to lipopolysaccharide; • metilação; • dopamine metabolic process; • response to pain; • memória a curto prazo; • negative regulation of renal sodium excretion; • dopamine catabolic process; • positive regulation of homocysteine metabolic process; • catecholamine catabolic process; • response to estrogen;
	Sources:Amigo / QuickGO
Padrão de expressão RNA
	; ; ; ;
	Mais dados de referência de expressão
Ortólogos
	1312
	n/a
	ENSG00000093010
	n/a
	P21964
	n/a
	NM_000754; NM_001135161; NM_001135162; NM_007310; NM_001362828
	n/a
	NP_000745; NP_001128633; NP_001128634; NP_009294; NP_001349757
	n/a
	Wikidata
Ver/Editar Humano

A Catecol O-Metiltransferase, ou simplesmente COMT, é uma das muitas enzimas que degradam catecolaminas (dopamina, epinefrina e norepinefrina).^[3]

Factos rápidos COMT, Estruturas disponíveis ...

[3]

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[2]

Catecol O-Metiltransferase

Referências

Leitura adicional

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