Fator de crescimento nervoso

Factor de crescimento nervoso (polipéptido beta)
	Dímero de NGF (a partir de PDB 1SG1)
Estruturas disponíveis
PDB	Busca de ortólogos: PDBe, RCSB
Lista de códigos PDB
	1SG1, 1WWW, 2IFG, 4EDW, 4EDX
Identificadores
Símbolos	NGF; Beta-NGF; HSAN5; NGFB
IDs externos	OMIM: 162030 MGI: 97321 HomoloGene: 1876 ChEMBL: 1649058 GeneCards: NGF Gene
Ontologia do gene
Função molecular	•receptor signaling protein activity; •nerve growth factor receptor binding; •growth factor activity;
Componente celular	•extracellular region; •extracellular space; •endosome; •Golgi lumen;
Processo biológico	•activation of MAPKK activity; •inflammatory response; •transmembrane receptor protein tyrosine kinase signaling pathway; •activation of phospholipase C activity; •small GTPase mediated signal transduction; •Ras protein signal transduction; •peripheral nervous system development; •memory; •adult locomotory behavior; •extrinsic apoptotic signaling pathway via death domain receptors; •response to radiation; •response to mechanical stimulus; •response to ozone; •positive regulation of gene expression; •sensory perception of pain; •positive regulation of protein autophosphorylation; •nerve growth factor processing; •response to lipopolysaccharide; •response to nicotine; •response to drug; •positive regulation of apoptotic process; •negative regulation of apoptotic process; •regulation of cysteine-type endopeptidase activity involved in apoptotic process; •response to peptide hormone; •negative regulation of neuron apoptotic process; •positive regulation of neuron differentiation; •positive regulation of axon extension; •negative regulation of cell cycle; •regulation of neurotransmitter secretion; •neurotrophin TRK receptor signaling pathway; •phosphatidylinositol-mediated signaling; •neuron projection morphogenesis; •regulation of axonogenesis; •positive regulation of axonogenesis; •positive regulation of sequence-specific DNA binding transcription factor activity; •response to glucocorticoid; •positive regulation of neurotrophin TRK receptor signaling pathway; •neuron apoptotic process; •response to electrical stimulus; •apoptotic signaling pathway; •extrinsic apoptotic signaling pathway in absence of ligand; •positive regulation of stem cell proliferation; •negative regulation of type B pancreatic cell apoptotic process;
	Sources: Amigo / QuickGO
Padrões de expressão do ARN
	Mais dados de expressão
Ortólogos
	v; d; e;

Fator de crescimento nervoso - com sigla (em inglês): NGF (de Nerve growth factor) é uma pequena proteína de secreção interna, importante para o crescimento, manutenção e sobrevivência de determinados neurônios (células nervosas). Também funciona como molécula de sinalização entre os neurônios.^[1] É um provável protótipo do fator de crescimento, dos quais foi um dos primeiros a ser descrito. Usado no singular trata de um fator específico, em contrapartida para o plural (fatores de crescimento nervoso), que se referem às neurotrofinas.^[2] Outros tipos de neurotrofinas conhecidos são o BNDF (Brain-Derived Neurotrophic Factor), a neurotrofina-3 (NT-3) e neurotrofina 4/5 (NT-4/5).

Factos rápidos Factor de crescimento nervoso (polipéptido beta), Estruturas disponíveis ...

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[2]

Fator de crescimento nervoso

Referências

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