Diamin oksidaza

Diamin oksidaza (EC 1.4.3.22, aminska oksidaza (nespecifična), CAO (nespecifična), Cu-sadržavajuća aminska oksidaza (nespecifična), bakarna aminska oksidaza (nespecifična), diaminska oksidaza (nespecifična), diamino oxhidraza (nespecifična), histaminaza, semikarbazid-senzitivna aminska oksidaza) je enzim sa sistematskim imenom histamin:kiseonik oksidoreduktaza (deaminacija).^{[1][2][3][4][5]} Ovaj enzim katalizuje sledeću hemijsku reakciju

histamin +H₂O + O₂ ${\displaystyle \rightleftharpoons }$ (imidazol-4-il)acetaldehid + NH₃ +H₂O₂

Diamin oksidaza
Identifikatori
EC broj	1.4.3.22
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

Ova grupa enzima oksiduje diamine, kao što je histamin, kao i neke primarne monoamine.

Reference

1. Zeller, E.A. (1963). „Diamine oxidases”. u: Boyer, P.D., Lardy, H. and Myrbäck, K.. The Enzymes. 8 (2nd izd.). New York: Academic Press. str. 313-335.
2. Crabbe, M.J., Waight, R.D., Bardsley, W.G., Barker, R.W., Kelly, I.D. and Knowles, P.F. (1976). „Human placental diamine oxidase. Improved purification and characterization of a copper- and manganese-containing amine oxidase with novel substrate specificity”. Biochem. J. 155: 679-687. PMID 182134.
3. Chassande, O., Renard, S., Barbry, P. and Lazdunski, M. (1994). „The human gene for diamine oxidase, an amiloride binding protein. Molecular cloning, sequencing, and characterization of the promoter”. J. Biol. Chem. 269: 14484-14489. PMID 8182053.
4. Houen, G. (1999). „Mammalian Cu-containing amine oxidases (CAOs): new methods of analysis, structural relationships, and possible functions”. APMIS Suppl. 96: 1-46. PMID 10668504.
5. Elmore, B.O., Bollinger, J.A. and Dooley, D.M. (2002). „Human kidney diamine oxidase: heterologous expression, purification, and characterization”. J. Biol. Inorg. Chem. 7: 565-579. PMID 12072962.

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Spoljašnje veze

• MeSH Diamine+oxidase