C-Myc维基百科,自由的 encyclopedia C-Myc或Myc是编码转录因子的调节基因。这一基因编码的蛋白在细胞核内被磷酸化,有多种功能:在细胞周期进程、细胞凋亡和细胞转化中发挥作用。[5] Quick Facts c-Myc, 已知的结构 ...c-Myc已知的结构PDB直系同源搜索: PDBe RCSB PDBID列表1A93、1EE4、1MV0、1NKP、2A93、2OR9、4Y7R识别号别名MYC;, MRTL, MYCC, bHLHe39, c-Myc, v-myc avian myelocytomatosis viral oncogene homolog, MYC proto-oncogene, bHLH transcription factor, Genes, myc, c-myc外部IDOMIM:190080 MGI:97250 HomoloGene:31092 GeneCards:MYC 基因位置(人类)染色体8号染色体[1]基因座8q24.21起始127,735,434 bp[1]终止127,742,951 bp[1]基因位置(小鼠)染色体小鼠15号染色体[2]基因座15 D1|15 26.19 cM起始61,857,240 bp[2]终止61,862,223 bp[2]基因本体分子功能• DNA结合• protein dimerization activity• DNA结合转录因子活性• DNA-binding transcription activator activity, RNA polymerase II-specific• 转录因子结合• RNA polymerase II cis-regulatory region sequence-specific DNA binding• E-box binding• 血浆蛋白结合• 大分子复合物结合• DNA-binding transcription factor activity, RNA polymerase II-specific• DNA结合转录阻遏物活性,RNA聚合酶II特异性细胞组分• 核质• 核仁• 细胞核• 大分子复合体生物学过程• Notch信号通路• 染色体重建• negative regulation of monocyte differentiation• positive regulation of metanephric cap mesenchymal cell proliferation• regulation of transcription, DNA-templated• regulation of telomere maintenance• positive regulation of epithelial cell proliferation• positive regulation of fibroblast proliferation• cellular response to UV• oxygen transport• negative regulation of apoptotic process• negative regulation of transcription by RNA polymerase II• chromosome organization• MAPK cascade• cellular response to DNA damage stimulus• positive regulation of cysteine-type endopeptidase activity involved in apoptotic process• branching involved in ureteric bud morphogenesis• negative regulation of cell division• fibroblast apoptotic process• positive regulation of mesenchymal cell proliferation• positive regulation of response to DNA damage stimulus• positive regulation of cell population proliferation• positive regulation of DNA biosynthetic process• 基因调节• canonical Wnt signaling pathway• negative regulation of stress-activated MAPK cascade• energy reserve metabolic process• response to growth factor• response to gamma radiation• negative regulation of fibroblast proliferation• positive regulation of transcription by RNA polymerase II• cellular iron ion homeostasis• beta-catenin-TCF complex assembly• transcription, DNA-templated• transcription by RNA polymerase II• regulation of transcription by RNA polymerase II• protein deubiquitination• positive regulation of transcription, DNA-templated• positive regulation of telomerase activity• positive regulation of gene expression• protein-DNA complex disassembly• ERK1 and ERK2 cascade• cellular response to hypoxia• G1/S transition of mitotic cell cycle• cytokine-mediated signaling pathway• positive regulation of DNA methylationSources:Amigo / QuickGO直系同源物种人类小鼠Entrez460917869EnsemblENSG00000136997ENSMUSG00000022346UniProtP01106P01108mRNA序列NM_002467NM_001354870NM_001177352NM_001177353NM_001177354NM_010849蛋白序列NP_002458NP_001341799NP_001170823NP_001170824NP_001170825NP_034979基因位置(UCSC)Chr 8: 127.74 – 127.74 MbChr 15: 61.86 – 61.86 MbPubMed查找[3][4]维基数据查看/编辑人类查看/编辑小鼠Close
C-Myc或Myc是编码转录因子的调节基因。这一基因编码的蛋白在细胞核内被磷酸化,有多种功能:在细胞周期进程、细胞凋亡和细胞转化中发挥作用。[5] Quick Facts c-Myc, 已知的结构 ...c-Myc已知的结构PDB直系同源搜索: PDBe RCSB PDBID列表1A93、1EE4、1MV0、1NKP、2A93、2OR9、4Y7R识别号别名MYC;, MRTL, MYCC, bHLHe39, c-Myc, v-myc avian myelocytomatosis viral oncogene homolog, MYC proto-oncogene, bHLH transcription factor, Genes, myc, c-myc外部IDOMIM:190080 MGI:97250 HomoloGene:31092 GeneCards:MYC 基因位置(人类)染色体8号染色体[1]基因座8q24.21起始127,735,434 bp[1]终止127,742,951 bp[1]基因位置(小鼠)染色体小鼠15号染色体[2]基因座15 D1|15 26.19 cM起始61,857,240 bp[2]终止61,862,223 bp[2]基因本体分子功能• DNA结合• protein dimerization activity• DNA结合转录因子活性• DNA-binding transcription activator activity, RNA polymerase II-specific• 转录因子结合• RNA polymerase II cis-regulatory region sequence-specific DNA binding• E-box binding• 血浆蛋白结合• 大分子复合物结合• DNA-binding transcription factor activity, RNA polymerase II-specific• DNA结合转录阻遏物活性,RNA聚合酶II特异性细胞组分• 核质• 核仁• 细胞核• 大分子复合体生物学过程• Notch信号通路• 染色体重建• negative regulation of monocyte differentiation• positive regulation of metanephric cap mesenchymal cell proliferation• regulation of transcription, DNA-templated• regulation of telomere maintenance• positive regulation of epithelial cell proliferation• positive regulation of fibroblast proliferation• cellular response to UV• oxygen transport• negative regulation of apoptotic process• negative regulation of transcription by RNA polymerase II• chromosome organization• MAPK cascade• cellular response to DNA damage stimulus• positive regulation of cysteine-type endopeptidase activity involved in apoptotic process• branching involved in ureteric bud morphogenesis• negative regulation of cell division• fibroblast apoptotic process• positive regulation of mesenchymal cell proliferation• positive regulation of response to DNA damage stimulus• positive regulation of cell population proliferation• positive regulation of DNA biosynthetic process• 基因调节• canonical Wnt signaling pathway• negative regulation of stress-activated MAPK cascade• energy reserve metabolic process• response to growth factor• response to gamma radiation• negative regulation of fibroblast proliferation• positive regulation of transcription by RNA polymerase II• cellular iron ion homeostasis• beta-catenin-TCF complex assembly• transcription, DNA-templated• transcription by RNA polymerase II• regulation of transcription by RNA polymerase II• protein deubiquitination• positive regulation of transcription, DNA-templated• positive regulation of telomerase activity• positive regulation of gene expression• protein-DNA complex disassembly• ERK1 and ERK2 cascade• cellular response to hypoxia• G1/S transition of mitotic cell cycle• cytokine-mediated signaling pathway• positive regulation of DNA methylationSources:Amigo / QuickGO直系同源物种人类小鼠Entrez460917869EnsemblENSG00000136997ENSMUSG00000022346UniProtP01106P01108mRNA序列NM_002467NM_001354870NM_001177352NM_001177353NM_001177354NM_010849蛋白序列NP_002458NP_001341799NP_001170823NP_001170824NP_001170825NP_034979基因位置(UCSC)Chr 8: 127.74 – 127.74 MbChr 15: 61.86 – 61.86 MbPubMed查找[3][4]维基数据查看/编辑人类查看/编辑小鼠Close