二肽基肽酶-4

二肽基肽酶-4（dipeptidyl peptidase-4，DPP-4）又称T细胞表面抗原CD26，是一种跨膜丝氨酸多肽酶，分布广泛，作用多向^[1]。可作为二肽酶水解多肽，从而调节肽类激素、神经肽、细胞因子和生长因子的活性，另可作为表面抗原与其他分子或蛋白共同合作，介导细胞与基质、细胞与细胞之间的相互作用。在免疫激活、炎症反应和肿瘤发生中起到各种调节作用^[2]。

Dipeptidyl-peptidase 4
人类DPP-4的带状结构图 来自PDB: 1PFQ​.
有效结构 PDB 直系同源检索：PDBe, RCSB PDB查询代码列表 1J2E​, 1N1M​, 1NU6​, 1NU8​, 1PFQ​, 1R9M​, 1R9N​, 1RWQ​, 1TK3​, 1TKR​, 1U8E​, 1W1I​, 1WCY​, 1X70​, 2AJL​, 2BGN​, 2BGR​, 2BUB​, 2FJP​, 2G5P​, 2G5T​, 2G63​, 2HHA​, 2I03​, 2I78​, 2IIT​, 2IIV​, 2JID​, 2OAG​, 2OGZ​, 2OLE​, 2ONC​, 2OPH​, 2OQI​, 2OQV​, 2P8S​, 2QJR​, 2QKY​, 2QOE​, 2QT9​, 2QTB​, 2RGU​, 2RIP​, 3BJM​, 3C43​, 3C45​, 3CCB​, 3CCC​, 3D4L​, 3EIO​, 3F8S​, 3G0B​, 3G0C​, 3G0D​, 3G0G​, 3H0C​, 3HAB​, 3HAC​, 3KWF​, 3KWJ​, 3NOX​, 3O95​, 3O9V​, 3OC0​, 3OPM​, 3Q0T​, 3Q8W​, 3QBJ​, 3SWW​, 3SX4​, 3VJK​, 3VJL​, 3VJM​, 3W2T​, 4A5S​, 4DSA​, 4DSZ​, 4DTC​, 4G1F​, 4J3J​, 4JH0​, 4KR0​, 4L72​, 4LKO​, 4N8D​, 4N8E​, 4PNZ​, 4PV7​, 4QZV​
标识
代号	DPP4; ADABP; ADCP2; CD26; DPPIV; TP103
扩展标识	遗传学：102720 鼠基因：94919 同源基因：3279 ChEMBL: 284 GeneCards: DPP4 Gene
EC编号	3.4.14.5
基因本体论描述 分子功能 · virus receptor activity · protease binding · serine-type endopeptidase activity · receptor binding · protein binding · serine-type peptidase activity · dipeptidyl-peptidase activity · identical protein binding · protein homodimerization activity 细胞成分 · lysosomal membrane · plasma membrane · focal adhesion · cell surface · membrane · integral component of membrane · apical plasma membrane · lamellipodium · endocytic vesicle · lamellipodium membrane · membrane raft · intercellular canaliculus · extracellular exosome · invadopodium membrane 生物过程 · behavioral fear response · response to hypoxia · proteolysis · positive regulation of cell proliferation · negative regulation of extracellular matrix disassembly · T cell costimulation · regulation of cell-cell adhesion mediated by integrin · locomotory exploration behavior · psychomotor behavior · T cell activation · endothelial cell migration · viral entry into host cell Sources: Amigo / QuickGO
RNA表达模式
更多表达数据
直系同源体
物种	人类	小鼠
Entrez	1803	13482
Ensembl	ENSG00000197635	ENSMUSG00000035000
UniProt	P27487	P28843
mRNA序列	NM_001935	NM_001159543
蛋白序列	NP_001926	NP_001153015
基因位置	Chr 2: 161.99 – 162.07 Mb	Chr 2: 62.33 – 62.41 Mb
PubMed查询	[1]	[2]
查 论 编

二肽基肽酶-4由DPPP4基因编码^[3]。DPP4与ATRN、FAP、DPP8和DPP9有关联^[4]。

延伸阅读

• Ansorge, S.; Bühling, F.; Kähne, T.; Lendeckel, U.; Reinhold, D.; Täger, M.; Wrenger, S. CD26/dipeptidyl peptidase IV in lymphocyte growth regulation. Advances in Experimental Medicine and Biology. 1997, 421: 127–140 [2021-11-10]. ISSN 0065-2598. PMID 9330689. doi:10.1007/978-1-4757-9613-1_17. （原始内容存档于2021-11-10）. （页面存档备份，存于互联网档案馆）
• Reinhold, Dirk; Kähne, Thilo; Steinbrecher, Andreas; Wrenger, Sabine; Neubert, Klaus; Ansorge, Siegfried; Brocke, Stefan. The role of dipeptidyl peptidase IV (DP IV) enzymatic activity in T cell activation and autoimmunity. Biological Chemistry. 2002-07, 383 (7-8): 1133–1138 [2021-11-10]. ISSN 1431-6730. PMID 12437097. doi:10.1515/BC.2002.123. （原始内容存档于2022-04-10）. （页面存档备份，存于互联网档案馆）
• Sato, Kazuya; Dang, Nam H. CD26: a novel treatment target for T-cell lymphoid malignancies? (Review). International Journal of Oncology. 2003-03, 22 (3): 481–497 [2021-11-10]. ISSN 1019-6439. PMID 12579300. （原始内容存档于2021-11-10）. （页面存档备份，存于互联网档案馆）
• De Meester, Ingrid; Lambeir, Anne-Marie; Proost, Paul; Scharpé, Simon. Dipeptidyl Peptidase IV Substrates. Back, Nathan (编). Dipeptidyl Aminopeptidases in Health and Disease 524. Boston, MA: Springer US. 2004: 3–17. ISBN 978-0-306-47717-1. PMID 12675218. doi:10.1007/0-306-47920-6_1.
• Koch, Sina; Anthonsen, Dorit; Skovbjerg, Hanne; Sjöström, Hans. On the Role of Dipeptidyl Peptidase IV in the Digestion of an Immunodominant Epitope in Celiac Disease. Back, Nathan (编). Dipeptidyl Aminopeptidases in Health and Disease 524. Boston: Kluwer Academic Publishers. 2004: 181–187. ISBN 978-0-306-47717-1. PMID 12675238. doi:10.1007/0-306-47920-6_22 （英语）.
• Pro, B.; Dang, N. H. CD26/dipeptidyl peptidase IV and its role in cancer. Histology and Histopathology. 2004-10, 19 (4): 1345–1351 [2021-11-10]. ISSN 0213-3911. PMID 15375776. doi:10.14670/HH-19.1345. （原始内容存档于2022-01-20）. （页面存档备份，存于互联网档案馆）