甲状腺激素α受体

甲状腺激素α受体
已知的结构
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	1NAV、2H77、2H79、3HZF、3ILZ、3JZB、4LNW、4LNX
识别号
别名	THRA；, AR7, CHNG6, EAR7, ERB-T-1, ERBA, ERBA1, NR1A1, THRA1, THRA2, c-ERBA-1, thyroid hormone receptor, alpha, thyroid hormone receptor alpha, TRalpha
外部ID	OMIM：190120 MGI：98742 HomoloGene：37747 GeneCards：THRA
相关疾病
	congenital nongoitrous hypothryoidism 6
为以下药物的标靶
	反三碘甲状腺原氨酸、替拉曲可、三碘甲腺原氨酸、左旋甲状腺素钠
基因位置（人类）
染色体	17号染色体
终止	40,093,867 bp
基因位置（小鼠）
染色体	小鼠11号染色体
终止	98,659,832 bp
RNA表达模式
	; ;
	查阅更多表达数据
基因本体
分子功能	• transcription cis-regulatory region binding; • 血浆蛋白结合; • single-stranded RNA binding; • 锌离子结合; • chromatin DNA binding; • nuclear receptor activity; • steroid receptor RNA activator RNA binding; • 转录因子结合; • TBP-class protein binding; • steroid hormone receptor activity; • DNA结合; • protein domain specific binding; • sequence-specific DNA binding; • 金属离子结合; • DNA结合转录因子活性; • thyroid hormone binding; • DNA-binding transcription factor activity, RNA polymerase II-specific; • 大分子复合物结合; • RNA polymerase II transcription regulatory region sequence-specific DNA binding; • nuclear receptor coactivator activity; • signaling receptor activity;
细胞组分	• 细胞质; • 核质; • 细胞核; • 细胞质基质; • RNA polymerase II transcription regulator complex;
生物学过程	• regulation of transcription by RNA polymerase II; • response to cold; • cytoplasmic sequestering of transcription factor; • hormone-mediated signaling pathway; • regulation of thyroid hormone mediated signaling pathway; • 甲状旁腺的发生; • regulation of transcription, DNA-templated; • 成骨作用; • female courtship behavior; • cartilage condensation; • negative regulation of RNA polymerase II transcription preinitiation complex assembly; • type I pneumocyte differentiation; • transcription, DNA-templated; • steroid hormone mediated signaling pathway; • transcription by RNA polymerase II; • regulation of lipid catabolic process; • regulation of heart contraction; • animal organ morphogenesis; • positive regulation of female receptivity; • 学习和记忆; • regulation of myeloid cell apoptotic process; • positive regulation of transcription by RNA polymerase II; • transcription initiation from RNA polymerase II promoter; • erythrocyte differentiation; • negative regulation of DNA-templated transcription, initiation; • positive regulation of myotube differentiation; • negative regulation of transcription, DNA-templated; • intracellular receptor signaling pathway; • negative regulation of transcription by RNA polymerase II; • thyroid hormone mediated signaling pathway; • multicellular organism development; • brain development; • 细胞分化; • response to lipid; • positive regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
直系同源
	7067
	21833
	ENSG00000126351
	ENSMUSG00000058756
	P10827
	P63058
	NM_199334; NM_001190918; NM_001190919; NM_003250
	NM_178060; NM_001313983
	NP_001177847; NP_001177848; NP_003241; NP_955366
	NP_001300912; NP_835161
	维基数据
查看/编辑人类	查看/编辑小鼠