胰岛素样生长因子1

胰岛素样生长因子1
已知的结构
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	1B9G、1GZR、1GZY、1GZZ、1H02、1H59、1IMX、1PMX、1TGR、1WQJ、2DSR、2GF1、3GF1、3LRI、1BQT、4XSS
识别号
别名	IGF1；, IGF-I, IGF1A, IGFI, MGF, insulin like growth factor 1, IGF
外部ID	OMIM：147440 MGI：96432 HomoloGene：515 GeneCards：IGF1
相关疾病
	growth delay due to insulin-like growth factor type 1 deficiency
基因位置（人类）
染色体	12号染色体
终止	102,481,744 bp
基因位置（小鼠）
染色体	小鼠10号染色体
终止	87,772,904 bp
RNA表达模式
	; ; ; ;
	查阅更多表达数据
基因本体
分子功能	• hormone activity; • insulin receptor binding; • 生长因子活性; • integrin binding; • 血浆蛋白结合; • insulin-like growth factor receptor binding;
细胞组分	• 细胞外区域; • exocytic vesicle; • insulin-like growth factor binding protein complex; • platelet alpha granule lumen; • insulin-like growth factor ternary complex; • alphav-beta3 integrin-IGF-1-IGF1R complex; • 细胞膜; • 细胞外空间;
生物学过程	• positive regulation of transcription regulatory region DNA binding; • 骨骼系统的发生; • positive regulation of glucose import; • muscle organ development; • positive regulation of Ras protein signal transduction; • response to heat; • positive regulation of cardiac muscle hypertrophy; • positive regulation of smooth muscle cell migration; • 脱氧核糖核酸复制; • positive regulation of insulin-like growth factor receptor signaling pathway; • phosphatidylinositol 3-kinase signaling; • positive regulation of DNA binding; • Ras protein signal transduction; • 细胞增殖; • positive regulation of mitotic nuclear division; • positive regulation of trophectodermal cell proliferation; • positive regulation of glycogen biosynthetic process; • positive regulation of fibroblast proliferation; • ERK1 and ERK2 cascade; • negative regulation of extrinsic apoptotic signaling pathway; • cell activation; • negative regulation of oocyte development; • positive regulation of transcription, DNA-templated; • bone mineralization involved in bone maturation; • positive regulation of peptidyl-tyrosine phosphorylation; • positive regulation of MAPK cascade; • proteoglycan biosynthetic process; • positive regulation of activated T cell proliferation; • positive regulation of epithelial cell proliferation; • negative regulation of release of cytochrome c from mitochondria; • protein stabilization; • myotube cell development; • positive regulation of DNA replication; • myoblast proliferation; • skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration; • positive regulation of protein secretion; • positive regulation of glycoprotein biosynthetic process; • 基因调节; • phosphatidylinositol-mediated signaling; • positive regulation of smooth muscle cell proliferation; • 肌肉肥大; • Akt/PKB信号通路; • regulation of multicellular organism growth; • positive regulation of cell migration; • platelet degranulation; • positive regulation of calcineurin-NFAT signaling cascade; • positive regulation of phosphatidylinositol 3-kinase signaling; • myoblast differentiation; • glycolate metabolic process; • positive regulation of glycolytic process; • negative regulation of smooth muscle cell apoptotic process; • 信号转导; • positive regulation of transcription by RNA polymerase II; • positive regulation of cell growth involved in cardiac muscle cell development; • positive regulation of cell population proliferation; • positive regulation of osteoblast differentiation; • activation of protein kinase B activity; • insulin-like growth factor receptor signaling pathway; • negative regulation of apoptotic process; • positive regulation of tyrosine phosphorylation of STAT protein; • regulation of signaling receptor activity; • positive regulation of gene expression; • negative regulation of gene expression; • cellular response to amyloid-beta; • positive regulation of vascular associated smooth muscle cell proliferation; • negative regulation of vascular associated smooth muscle cell apoptotic process; • 白细胞介素-1β产生的负调控; • 肿瘤坏死因子产生的负调控; • negative regulation of neuroinflammatory response; • negative regulation of amyloid-beta formation;
	Sources:Amigo / QuickGO
直系同源
	3479
	16000
	ENSG00000017427
	ENSMUSG00000020053
	P05019
	P05017
	NM_000618; NM_001111283; NM_001111284; NM_001111285
NM_001111274; NM_001111275; NM_001111276; NM_010512; NM_184052;
	NM_001314010
	NP_000609; NP_001104753; NP_001104754; NP_001104755
	NP_001104744; NP_001104745; NP_001104746; NP_001300939; NP_034642
	维基数据
查看/编辑人类	查看/编辑小鼠

胰岛素样生长因子1（英语：Insulin-like growth factor 1，IGF-1）也被称为生长调节素C（somatomedin C），是一个由人类基因 IGF1 编码的蛋白质^[6]^[7]。在1970年代，IGF-1也曾经被称为“酸硫化（英语：sulfation）因子”^[8]，并认为其作用为“不受抑制的胰岛样活力”（nonsuppressible insulin-like activity，NSILA）。