腺苷A2A受體

腺苷A2A受体
已知的结构
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	2YDO、2YDV、3EML、3PWH、3QAK、3REY、3RFM、3UZA、3UZC、3VG9、3VGA、4EIY、4UG2、4UHR、5IU4、5IU7、5IUA、5IU8、5IUB
识别号
别名	ADORA2A；, adenosine A2a receptor, A2aR, ADORA2, RDC8
外部ID	OMIM：102776 MGI：99402 HomoloGene：20166 GeneCards：ADORA2A
为以下药物的标靶
	腺苷、BAY 60-6583、Regadenoson、UK-432,097、CCPA、CGS-21680、cyclopentyladenosine、咖啡因、CGS 15943、8-环戊基-1,3-二丙基黄嘌呤、flavone、高良姜素、istradefylline、桑色素、瑞德南特、rolofylline、樱花素、sch-442416、sch-58261、茶碱、ZM-241385
基因位置（人类）
染色体	22号染色体
终止	24,442,357 bp
基因位置（小鼠）
染色体	小鼠10号染色体
终止	75,170,618 bp
RNA表达模式
	查阅更多表达数据
基因本体
分子功能	• G protein-coupled adenosine receptor activity; • G protein-coupled receptor activity; • signal transducer activity; • 血浆蛋白结合; • 相同蛋白质结合; • 酶结合; • alpha-actinin binding; • type 5 metabotropic glutamate receptor binding; • protein heterodimerization activity;
细胞组分	• integral component of membrane; • 膜; • 细胞膜; • integral component of plasma membrane; • 中间纤维; • 内膜系统; • 突触后致密物质; • 轴突; • 树突; • axolemma; • asymmetric synapse; • presynaptic membrane; • soma; • postsynaptic membrane; • presynaptic active zone; • integral component of postsynaptic membrane; • integral component of presynaptic membrane; • glutamatergic synapse; • Golgi membrane;
生物学过程	• cAMP biosynthetic process; • G protein-coupled adenosine receptor signaling pathway; • sensory perception; • adenylate cyclase-modulating G protein-coupled receptor signaling pathway; • cell-cell signaling; • 凝血; • blood circulation; • cellular defense response; • central nervous system development; • 吞噬作用; • inflammatory response; • 信号转导; • 细胞凋亡; • synaptic transmission, dopaminergic; • response to amphetamine; • regulation of transcription, DNA-templated; • negative regulation of protein kinase activity; • protein kinase C-activating G protein-coupled receptor signaling pathway; • synaptic transmission, cholinergic; • locomotory behavior; • negative regulation of cell population proliferation; • positive regulation of glutamate secretion; • positive regulation of acetylcholine secretion, neurotransmission; • regulation of norepinephrine secretion; • response to caffeine; • positive regulation of synaptic transmission, GABAergic; • synaptic transmission, glutamatergic; • positive regulation of urine volume; • positive regulation of renal sodium excretion; • negative regulation of locomotion; • 血管舒张; • eating behavior; • negative regulation of vascular permeability; • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; • response to alkaloid; • negative regulation of neuron apoptotic process; • positive regulation of circadian sleep/wake cycle, sleep; • negative regulation of alpha-beta T cell activation; • astrocyte activation; • neuron projection morphogenesis; • positive regulation of protein secretion; • negative regulation of inflammatory response; • regulation of mitochondrial membrane potential; • membrane depolarization; • regulation of calcium ion transport; • positive regulation of synaptic transmission, glutamatergic; • 兴奋性动作电位; • 抑制性突触; • 前脉冲抑制; • positive regulation of apoptotic signaling pathway; • G protein-coupled receptor signaling pathway; • adenylate cyclase-activating G protein-coupled receptor signaling pathway; • positive regulation of long-term synaptic potentiation; • regulation of synaptic vesicle exocytosis;
	Sources:Amigo / QuickGO
直系同源
	135
	11540
	ENSG00000128271
	ENSMUSG00000020178
	P29274
	Q60613
	NM_000675; NM_001278497; NM_001278498; NM_001278499; NM_001278500
	NM_009630; NM_001331095; NM_001331096
	NP_000666; NP_001265426; NP_001265427; NP_001265428; NP_001265429
	NP_001318024; NP_001318025; NP_033760
	维基数据
查看/编辑人类	查看/编辑小鼠

腺苷A_2A受体(adenosine A_2A receptor)，也称为ADORA2A，是一种腺苷受体，也表示编码它的人类基因。^[6]^[7]

事实速览 腺苷A2A受体, 已知的结构 ...

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腺苷A2A受體

参考资料

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外部链接

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