视黄酸受体α

视黄酸受体α
已知的结构
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	1DKF、1DSZ、3A9E、3KMR、3KMZ、4DQM、5K13
识别号
别名	RARA；, NR1B1, RAR, retinoic acid receptor alpha, RARalpha
外部ID	OMIM：180240 MGI：97856 HomoloGene：20262 GeneCards：RARA
为以下药物的标靶
	阿达帕林、alitretinoin、tamibarotene、他扎罗汀、维A酸
基因位置（人类）
染色体	17号染色体
终止	40,357,643 bp
基因位置（小鼠）
染色体	小鼠11号染色体
终止	98,865,768 bp
RNA表达模式
	; ; ; ;
	查阅更多表达数据
基因本体
分子功能	• retinoic acid binding; • transcription corepressor activity; • protein domain specific binding; • DNA结合转录因子活性; • nuclear receptor activity; • mRNA 5'-UTR binding; • signaling receptor binding; • RNA polymerase II transcription regulatory region sequence-specific DNA binding; • retinoic acid-responsive element binding; • 转录因子结合; • 金属离子结合; • steroid hormone receptor activity; • 酶结合; • 锌离子结合; • 血浆蛋白结合; • DNA结合; • sequence-specific DNA binding; • 转录共激活因子活性; • protein kinase A binding; • protein kinase B binding; • translation repressor activity, mRNA regulatory element binding; • alpha-actinin binding; • protein heterodimerization activity; • chromatin DNA binding; • DNA-binding transcription factor activity, RNA polymerase II-specific; • histone deacetylase binding; • transcription cis-regulatory region binding; • nuclear receptor coactivator activity; • signaling receptor activity;
细胞组分	• 细胞质; • actin cytoskeleton; • 细胞质的核周区域; • neuron projection; • 细胞核; • cell surface; • 核质; • soma; • 树突; • 细胞质基质; • RNA polymerase II transcription regulator complex;
生物学过程	• growth plate cartilage development; • germ cell development; • cellular response to retinoic acid; • ureteric bud development; • positive regulation of interleukin-5 production; • prostate gland development; • 四肢的发生; • apoptotic cell clearance; • chondroblast differentiation; • regulation of granulocyte differentiation; • protein phosphorylation; • response to vitamin A; • face development; • 精子发生; • response to ethanol; • negative regulation of cell population proliferation; • steroid hormone mediated signaling pathway; • regulation of apoptotic process; • response to cytokine; • negative regulation of translation; • regulation of transcription, DNA-templated; • negative regulation of cell differentiation; • negative regulation of gene expression; • transcription, DNA-templated; • cellular response to estrogen stimulus; • positive regulation of transcription, DNA-templated; • positive regulation of cell cycle; • regulation of myelination; • positive regulation of neuron differentiation; • 肿瘤坏死因子产生的负调控; • transcription initiation from RNA polymerase II promoter; • trachea cartilage development; • glandular epithelial cell development; • male gonad development; • negative regulation of cartilage development; • response to retinoic acid; • negative regulation of granulocyte differentiation; • multicellular organism growth; • female pregnancy; • negative regulation of apoptotic process; • negative regulation of transcription by RNA polymerase II; • positive regulation of interleukin-4 production; • regulation of synaptic plasticity; • outflow tract septum morphogenesis; • negative regulation of transcription, DNA-templated; • negative regulation of interferon-gamma production; • response to estradiol; • negative regulation of translational initiation; • embryonic camera-type eye development; • positive regulation of interleukin-13 production; • neural tube closure; • positive regulation of binding; • retinoic acid receptor signaling pathway; • positive regulation of gene expression; • Sertoli cell fate commitment; • positive regulation of cell population proliferation; • positive regulation of T-helper 2 cell differentiation; • ventricular cardiac muscle cell differentiation; • liver development; • cellular response to lipopolysaccharide; • bone development; • hippocampus development; • 信号转导; • positive regulation of transcription by RNA polymerase II; • multicellular organism development; • hormone-mediated signaling pathway; • 细胞分化; • response to lipid; • gland development; • bone morphogenesis; • epithelium development;
	Sources:Amigo / QuickGO
直系同源
	5914
	19401
	ENSG00000131759
	ENSMUSG00000037992
	P10276; Q6I9R7
	P11416
	NM_000964; NM_001024809; NM_001033603; NM_001145301; NM_001145302
	NM_001176528; NM_001177302; NM_001177303; NM_009024; NM_001361954
NP_000955; NP_001019980; NP_001138773; NP_001138774; NP_000955.1;
	NP_001138773.1
	NP_001169999; NP_001170773; NP_001170774; NP_033050; NP_001348883
	维基数据
查看/编辑人类	查看/编辑小鼠

视黄酸受体α（英语：Retinoic acid receptor alpha，RAR-α），也称为NR1B1（核受体第一亚族B组成员1，nuclear receptor subfamily 1, group B, member 1）是一个核受体，在人类基因组中由 RARA 基因编码。^[6]^[7]

事实速览 视黄酸受体α, 已知的结构 ...

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视黄酸受体α

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