CD61

CD61
已知的结构
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	4O02、1JV2、1KUP、1KUZ、1L5G、1M1X、1M8O、1MIZ、1MK7、1MK9、1S4X、1TYE、1U8C、2K9J、2KNC、2KV9、2L1C、2L91、2LJD、2LJE、2LJF、2MTP、2Q6W、2RMZ、2RN0、2VC2、2VDK、2VDL、2VDM、2VDN、2VDP、2VDQ、2VDR、3FCS、3FCU、3IJE、3NID、3NIF、3NIG、3T3M、3T3P、3ZDX、3ZDY、3ZDZ、3ZE0、3ZE1、3ZE2、4CAK、4G1E、4G1M、4MMX、4MMY、4MMZ、5HDB、4Z7Q、4Z7O、4Z7N
识别号
别名	ITGB3；, BDPLT16, BDPLT2, CD61, GP3A, GPIIIa, GT, integrin subunit beta 3, BDPLT24, GT2
外部ID	OMIM：173470 MGI：96612 HomoloGene：55444 GeneCards：ITGB3
相关疾病
	血小板无力症、platelet-type bleeding disorder 16
为以下药物的标靶
	cilengitide、依非巴特、tirofiban hydrochloride hydrate
基因位置（人类）
染色体	17号染色体
终止	47,313,743 bp
基因位置（小鼠）
染色体	小鼠11号染色体
终止	104,561,302 bp
RNA表达模式
	; ; ; ;
	查阅更多表达数据
基因本体
分子功能	• vascular endothelial growth factor receptor 2 binding; • fibronectin binding; • virus receptor activity; • extracellular matrix binding; • protein disulfide isomerase activity; • 蛋白酶结合; • platelet-derived growth factor receptor binding; • 血浆蛋白结合; • 相同蛋白质结合; • 酶结合; • cell adhesion molecule binding; • neuregulin binding; • coreceptor activity; • fibroblast growth factor binding; • insulin-like growth factor I binding; • C-X3-C chemokine binding; • integrin binding; • fibrinogen binding;
细胞组分	• integral component of membrane; • cell projection; • alphav-beta3 integrin-vitronectin complex; • 膜; • 粘着斑; • 黑色素体; • receptor complex; • 细胞膜; • integral component of plasma membrane; • ruffle membrane; • cell surface; • 细胞连接; • integrin complex; • platelet alpha granule membrane; • integrin alphav-beta3 complex; • 外排体; • lamellipodium membrane; • 细胞核; • microvillus membrane; • filopodium membrane; • alphav-beta3 integrin-IGF-1-IGF1R complex; • alphav-beta3 integrin-PKCalpha complex; • alphav-beta3 integrin-HMGB1 complex; • glutamatergic synapse; • 突触;
生物学过程	• negative regulation of lipoprotein metabolic process; • apolipoprotein A-I-mediated signaling pathway; • positive regulation of vascular endothelial growth factor receptor signaling pathway; • positive regulation of protein phosphorylation; • regulation of cell migration; • negative chemotaxis; • positive regulation of endothelial cell proliferation; • tube development; • heterotypic cell-cell adhesion; • angiogenesis involved in wound healing; • 伤口愈合; • platelet degranulation; • 凝血; • extracellular matrix organization; • smooth muscle cell migration; • positive regulation of endothelial cell migration; • 增殖; • cell-substrate adhesion; • vascular endothelial growth factor receptor signaling pathway; • 细胞粘附; • positive regulation of peptidyl-tyrosine phosphorylation; • mesodermal cell differentiation; • cell-substrate junction assembly; • integrin-mediated signaling pathway; • negative regulation of lipid storage; • substrate adhesion-dependent cell spreading; • negative regulation of lipid transport; • cell-matrix adhesion; • viral process; • regulation of bone resorption; • platelet aggregation; • 细胞迁移; • negative regulation of macrophage derived foam cell differentiation; • activation of protein kinase activity; • leukocyte migration; • cell adhesion mediated by integrin; • platelet activation; • apoptotic cell clearance; • regulation of postsynaptic neurotransmitter receptor internalization; • regulation of protein localization; • regulation of serotonin uptake;
	Sources:Amigo / QuickGO
直系同源
	3690
	16416
	ENSG00000259207
	ENSMUSG00000020689
	P05106
	O54890
	NM_000212
	NM_016780
	NP_000203
	NP_058060
	维基数据
查看/编辑人类	查看/编辑小鼠

整联蛋白β-3（Integrin β3）或 CD61（Cluster of differentiation 61）是一种蛋白质，在人类基因组中由 ITGB3 基因编码。^[7]CD61 是一种在血小板上表达的分化簇。^[8]

事实速览 CD61, 已知的结构 ...

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CD61

参考文献

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外部链接

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